Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3581202 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
358120235827311530hypothetical proteinBLASTP
35831593584025867ferrodoxin oxidoreductase beta subunitQuickGO ontologyBLASTP
358401235857691758pyruvate ferredoxin oxidoreductase alpha subunit putativeQuickGO ontologyBLASTP
35859973586920924renal dipeptidase family proteinQuickGO ontologyBLASTP
35869803587240261stage v sporulation protein sQuickGO ontologyBLASTP
35873903588184795phosphoesterase family proteinQuickGO ontologyBLASTP
358835035899121563hypothetical proteinBLASTP
359189835931361239competence damage-inducible protein AQuickGO ontologyBLASTP
35931573593735579cdp-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
35937993594710912hypothetical proteinBLASTP
35947323595517786act domain proteinQuickGO ontologyBLASTP
35956573595905249hypothetical proteinBLASTP
359598135966947143-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
359679835980841287zinc protease insulinase familyQuickGO ontologyBLASTP
359808535993591275hypothetical proteinBLASTP