Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3462624 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
346262434646302007hypothetical proteinBLASTP
346470634673572652prophage lambdaba01 minor structural proteinQuickGO ontologyBLASTP
346887634713112436prophage lambdaba01 membrane protein putativeQuickGO ontologyBLASTP
347152634727731248hypothetical proteinBLASTP
34727893472950162hypothetical proteinBLASTP
34729943473365372hypothetical proteinBLASTP
34733703473963594prophage lambdaba01 major tail protein putativeQuickGO ontologyBLASTP
34739643474293330hypothetical proteinBLASTP
34742903474646357hypothetical proteinBLASTP
34746393474938300hypothetical proteinBLASTP
34749353475213279hypothetical proteinBLASTP
34752103475500291hypothetical proteinBLASTP
347553734767001164phage major capsid protein putativeQuickGO ontologyBLASTP
34767143477298585prophage lambdaba01 prohead protease putativeQuickGO ontologyBLASTP
347726434784751212hypothetical proteinBLASTP
347849134801791689prophage lambdaba01 terminase large subunit putativeQuickGO ontologyBLASTP
34801763480547372hypothetical proteinBLASTP
34807133480838126hypothetical proteinBLASTP
34813403481501162hypothetical proteinBLASTP
34817733482195423hypothetical proteinBLASTP
34822823482707426hypothetical proteinBLASTP
34828283483106279hypothetical proteinBLASTP
34830753483272198hypothetical protein
34836753484502828hypothetical proteinBLASTP
34845663485549984hypothetical proteinBLASTP
34855823485914333hypothetical proteinBLASTP
34860553486690636hypothetical proteinBLASTP