Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3414568 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
341456834160851518histidine ammonia-lyaseQuickGO ontologyBLASTP
34161903416630441anti-terminator HutPQuickGO ontologyBLASTP
34168243417771948hypothetical proteinBLASTP
34177853418357573thijpfpi family proteinQuickGO ontologyBLASTP
34183543418854501hypothetical proteinBLASTP
34188263419041216hypothetical proteinBLASTP
34191393419435297hypothetical proteinBLASTP
34195393419979441hypothetical proteinBLASTP
342000934210881080hypothetical proteinBLASTP
34213563421583228conserved repeat domain proteinQuickGO ontologyBLASTP
34216453421962318hypothetical proteinBLASTP
34221703422298129hypothetical proteinBLASTP
34224193422649231hypothetical proteinBLASTP
342261534289176303conserved repeat domain proteinQuickGO ontologyBLASTP
34289803429486507ccdc proteinQuickGO ontologyBLASTP
34295773430284708cytochrome c-type biogenesis protein ccdaQuickGO ontologyBLASTP
34304893431064576hypothetical proteinBLASTP
34312953432200906als operon regulatory protein alsr putativeQuickGO ontologyBLASTP
34323533432718366holin-like proteinQuickGO ontologyBLASTP
34327153433392678hypothetical proteinBLASTP
34334053433818414muttnudix family proteinQuickGO ontologyBLASTP
34339603434160201hypothetical proteinBLASTP
34353423435488147hypothetical proteinBLASTP
343565334373801728n-acetylmuramoyl-l-alanine amidase family 2QuickGO ontologyBLASTP
34375963438162567hypothetical proteinBLASTP
34381693439005837hypothetical proteinBLASTP
343930734410701764abc transporter atp-bindingpermease proteinQuickGO ontologyBLASTP
344107034428211752abc transporter atp-bindingpermease proteinQuickGO ontologyBLASTP