Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3321033 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
332103333228861854squalene-hopene cyclaseQuickGO ontologyBLASTP
33229863323411426hypothetical proteinBLASTP
33234913324432942rard proteinQuickGO ontologyBLASTP
33245233324723201hypothetical proteinBLASTP
33249403325338399hypothetical proteinBLASTP
33253813325605225hypothetical proteinBLASTP
332562133266701050mrp proteinQuickGO ontologyBLASTP
33267373326973237molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
33269783327442465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
332742333287301308molybdopterin biosynthesis protein moeaQuickGO ontologyBLASTP
332874933297651017molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
33297903330569780formate transporter putativeQuickGO ontologyBLASTP
33305563330663108hypothetical proteinBLASTP
333075933317751017molybdenum cofactor biosynthesis protein aQuickGO ontologyBLASTP
33317963332593798formate dehydrogenase accessory proteinQuickGO ontologyBLASTP
33326103332954345hypothetical proteinBLASTP
33330703333552483hypothetical proteinBLASTP
333356433365032940molybdopterin oxidoreductase family proteinQuickGO ontologyBLASTP
33364723336663192hypothetical proteinBLASTP
333680133383391539spore germination proteinQuickGO ontologyBLASTP
333833633394331098spore germination proteinQuickGO ontologyBLASTP
333943433405701137spore germination proteinQuickGO ontologyBLASTP
33406503340784135hypothetical proteinBLASTP
334084233443123471hypothetical proteinBLASTP
334427833464702193hypothetical proteinBLASTP