Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:2716885 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27202542720820567transcriptional regulator tetr familyQuickGO ontologyBLASTP
272109027222471158acetyltransferase gnat familyQuickGO ontologyBLASTP
2722433272372212903-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
272373927248751137prephenate dehydrogenaseQuickGO ontologyBLASTP
272483227259321101putative aminotransferaseQuickGO ontologyBLASTP
272595127271231173chorismate synthaseQuickGO ontologyBLASTP
2727246272734499hypothetical proteinBLASTP
2727408272848410773-deoxy-7-phosphoheptulonate synthaseQuickGO ontologyBLASTP
272931627318652550hypothetical proteinBLASTP
27319092732826918hypothetical proteinBLASTP
27329762733413438hypothetical proteinBLASTP
27335622734092531isochorismatase family proteinQuickGO ontologyBLASTP
27341092734642534acetyltransferase gnat familyQuickGO ontologyBLASTP
27346622734961300hypothetical proteinBLASTP
27350632735578516hypothetical proteinBLASTP
273563027369521323hypothetical proteinBLASTP