Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:2175967 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21759672176302336hypothetical proteinBLASTP
21765982176810213hypothetical proteinBLASTP
21768802177086207hypothetical proteinBLASTP
217755521800172463penicillin-binding protein 1aQuickGO ontologyBLASTP
218063221817771146major facilitator family transporterQuickGO ontologyBLASTP
21817932182083291hypothetical proteinBLASTP
218248621836041119citrate synthaseQuickGO ontologyBLASTP
2183703218513914372-methylcitrate dehydrataseQuickGO ontologyBLASTP
21851582186066909carboxyvinyl-carboxyphosphonate phosphorylmutaseQuickGO ontologyBLASTP
218622121879301710acyl-coa dehydrogenaseQuickGO ontologyBLASTP
218794721888378912-hydroxy-3-oxopropionate reductaseQuickGO ontologyBLASTP
218887421903341461methylmalonic acid semialdehyde dehydrogenaseQuickGO ontologyBLASTP
21904052191037633homoserinethreonine efflux protein putativeQuickGO ontologyBLASTP
219122121922761056enoyl-CoA hydrataseQuickGO ontologyBLASTP
21925932192850258hypothetical proteinBLASTP
21930342193273240hypothetical proteinBLASTP
219328921944461158exonuclease sbcd putativeQuickGO ontologyBLASTP
219444321975323090exonuclease putativeQuickGO ontologyBLASTP
21979012198101201hypothetical proteinBLASTP