Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:1523060 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1523060153811315054conserved repeat domain proteinQuickGO ontologyBLASTP
15382361539096861acetyltransferase gnat familyQuickGO ontologyBLASTP
15391371539697561isochorismatase family proteinQuickGO ontologyBLASTP
15398791540139261hypothetical proteinBLASTP
15401421541053912transporter eama familyQuickGO ontologyBLASTP
15410611541447387ribonuclease HQuickGO ontologyBLASTP
15415171542389873lacx protein putativeQuickGO ontologyBLASTP
15425731543058486hypothetical proteinBLASTP
15432441543861618hypothetical proteinBLASTP
15438741544050177hypothetical proteinBLASTP
15440841544332249hypothetical proteinBLASTP
15444521544649198cold shock protein cspbQuickGO ontologyBLASTP
15449121545640729hypothetical proteinBLASTP
15457801546412633hypothetical proteinBLASTP
15464321546725294hypothetical proteinBLASTP
15468051547434630fatty acid hydroxylase-like proteinQuickGO ontologyBLASTP
15476581547999342hypothetical proteinBLASTP
154800215495521551sodiumsolute symporter family proteinQuickGO ontologyBLASTP