Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:1332768 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
133276813340031236protonglutamate symporter family proteinQuickGO ontologyBLASTP
133519913365421344potassium uptake protein trkh familyQuickGO ontologyBLASTP
13365761336947372hypothetical proteinBLASTP
13372341337641408hypothetical proteinBLASTP
13377261337839114hypothetical proteinBLASTP
13381921338440249hypothetical proteinBLASTP
13385581338797240hypothetical proteinBLASTP
13388571339093237hypothetical proteinBLASTP
13392131340109897branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP
134042513421251701acetolactate synthase large subunitQuickGO ontologyBLASTP
13421221342631510acetolactate synthase III small subunitQuickGO ontologyBLASTP
134265813436681011ketol-acid reductoisomeraseQuickGO ontologyBLASTP
1343670134519015212-isopropylmalate synthaseQuickGO ontologyBLASTP
1345268134633210653-isopropylmalate dehydrogenaseQuickGO ontologyBLASTP
134633213477261395isopropylmalate isomerase large subunitQuickGO ontologyBLASTP
13477041348285582isopropylmalate isomerase small subunitQuickGO ontologyBLASTP
134859613498581263ATP phosphoribosyltransferase regulatory subunitQuickGO ontologyBLASTP
13498341350469636ATP phosphoribosyltransferaseQuickGO ontologyBLASTP
135048113517701290histidinol dehydrogenaseQuickGO ontologyBLASTP
13517701352354585imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
13523551352984630imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
135295713536767201-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneamino imidazole-4-carboxamide isomeraseQuickGO ontologyBLASTP
13536701354428759imidazole glycerol phosphate synthase subunit HisFQuickGO ontologyBLASTP
135507613560921017histidinol-phosphataseQuickGO ontologyBLASTP