Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:1068000 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10680491069026978sugar-binding transcriptional regulator laci familyQuickGO ontologyBLASTP
10691021069263162hypothetical proteinBLASTP
10694101070144735hypothetical proteinBLASTP
10701541071143990lipoate-protein ligase a putativeQuickGO ontologyBLASTP
10713981071826429lipoprotein putativeQuickGO ontologyBLASTP
107198810735201533acyl-CoA synthaseQuickGO ontologyBLASTP
10737781073903126hypothetical proteinBLASTP
107397410750081035s-layer protein putativeQuickGO ontologyBLASTP
107533410820086675wall-associated protein putativeQuickGO ontologyBLASTP
10820161082495480hypothetical proteinBLASTP
10825391082877339hypothetical proteinBLASTP
10828951083014120hypothetical proteinBLASTP
10831491083685537wall-associated domain proteinQuickGO ontologyBLASTP
10836781083923246hypothetical proteinBLASTP
10839981084132135hypothetical proteinBLASTP
10853831085541159hypothetical proteinBLASTP
10859431086101159hypothetical proteinBLASTP
1086151108624696hypothetical proteinBLASTP
10864171086683267hypothetical proteinBLASTP
10881521089129978hd domain proteinQuickGO ontologyBLASTP
108916910902871119hypothetical proteinBLASTP