Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:1007140 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10071401008084945glyoxalase family proteinQuickGO ontologyBLASTP
10081281009105978glyoxylase family proteinQuickGO ontologyBLASTP
100932910104411113tpr domain proteinQuickGO ontologyBLASTP
10104381010569132hypothetical proteinBLASTP
10107971011672876hydrolase alphabeta fold familyQuickGO ontologyBLASTP
10117531011953201hypothetical proteinBLASTP
10121781012978801hypothetical proteinBLASTP
10133381013787450dna-binding proteinQuickGO ontologyBLASTP
10135721013787216hypothetical proteinBLASTP
10138851014445561glycerol uptake operon antiterminator regulatory proteinQuickGO ontologyBLASTP
10146741015495822glycerol uptake facilitator proteinQuickGO ontologyBLASTP
101550910169991491glycerol kinaseQuickGO ontologyBLASTP
101713310188151683glycerol-3-phosphate dehydrogenase aerobicQuickGO ontologyBLASTP
10190131019177165hypothetical proteinBLASTP
10196251020035411hypothetical proteinBLASTP
10200291020136108hypothetical proteinBLASTP
10202901020823534RNA polymerase sigma C factorQuickGO ontologyBLASTP
10208281021235408lineage-specific thermal regulator proteinQuickGO ontologyBLASTP
102131510224931179cell division protein ftswrodaspove familyQuickGO ontologyBLASTP
10225511023036486transcriptional regulator marr familyQuickGO ontologyBLASTP
10233211023686366hypothetical proteinBLASTP
102384810252391392major facilitator family transporterQuickGO ontologyBLASTP
102526210267101449drug resistance transporter emrbqaca familyQuickGO ontologyBLASTP