Pre_GI Gene

Some Help

Host: NC_007385 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007385:157516 Shigella sonnei Ss046 plasmid pSS_046, complete sequence

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1575161586041089hypothetical proteinBLASTP
158609159559951VirKQuickGO ontologyBLASTP
159624160568945MsbB2QuickGO ontologyBLASTP
1607221617531032IS630 ORFQuickGO ontologyBLASTP
161897162565669putative transposaseQuickGO ontologyBLASTP
162929163357429hypothetical protein
163371164087717IS186 ORF1QuickGO ontologyBLASTP
164665165012348putative antirestriction proteinQuickGO ontologyBLASTP
165069165371303IS600 ORF1QuickGO ontologyBLASTP
165512166225714IS600 ORF2QuickGO ontologyBLASTP
1664251686262202TraD proteinQuickGO ontologyBLASTP
168626169345720hypothetical proteinBLASTP
1693421736254284oriT nicking and unwinding protein fragmentQuickGO ontologyBLASTP
173682173984303IS600 ORF1QuickGO ontologyBLASTP
174125174838714IS600 ORF2QuickGO ontologyBLASTP
175043175879837oriT nicking and unwinding protein fragmentQuickGO ontologyBLASTP