Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:4530000 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
453004445320411998hypothetical proteinBLASTP
45322824532599318ribose 5-phosphate isomerase BQuickGO ontologyBLASTP
45326684532997330hypothetical proteinBLASTP
45331444533902759phosphonate metabolismQuickGO ontologyBLASTP
45339044534338435putative regulator phn operonQuickGO ontologyBLASTP
45343254534882558ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
453488245360181137phosphonate metabolismQuickGO ontologyBLASTP
45360154536695681ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
45368064537564759ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
45375614538406846phosphonate metabolismQuickGO ontologyBLASTP
453839945394631065phosphonate metabolismQuickGO ontologyBLASTP
45394634540047585phosphonate metabolismQuickGO ontologyBLASTP
45400444540496453phosphonate metabolismQuickGO ontologyBLASTP
45404974541222726putative transcriptional regulatorQuickGO ontologyBLASTP
45412434542022780membrane channel protein component of Pn transporterQuickGO ontologyBLASTP
454214845431641017periplasmic binding protein component of Pn transporterQuickGO ontologyBLASTP
45431894543977789ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
45447114545046336hypothetical proteinBLASTP
454545945476872229putative vimentinQuickGO ontologyBLASTP
45477174548550834hypothetical proteinBLASTP
454881445503161503low-affinity transport systemQuickGO ontologyBLASTP