Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:4095016 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
409501640963981383membrane-bound ATP synthase F1 sector beta subunitQuickGO ontologyBLASTP
40964194096838420membrane-bound ATP synthase F1 sector epsilon-subunitQuickGO ontologyBLASTP
409718940985591371N-acetyl glucosamine-1-phosphate uridyltransferaseQuickGO ontologyBLASTP
409872141005501830L-glutamineD-fructose-6-phosphate aminotransferaseQuickGO ontologyBLASTP
41009344101530597putative transposaseQuickGO ontologyBLASTP
410151741036252109putative transposaseQuickGO ontologyBLASTP
410362241052891668ATP-binding proteinQuickGO ontologyBLASTP
410529241068181527transposition proteinQuickGO ontologyBLASTP
410692741084351509transposition regulatory proteinQuickGO ontologyBLASTP
41104584111246789aminoglycoside-resistance proteinQuickGO ontologyBLASTP
411472541160711347IS4 ORFQuickGO ontologyBLASTP
41163634116935573putative major fimbrial subunitQuickGO ontologyBLASTP
41169834117285303putative fimbrial chaperoneQuickGO ontologyBLASTP
41172964117799504IS1 ORFQuickGO ontologyBLASTP
41194944120333840IS911 ORF2QuickGO ontologyBLASTP