Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:3956465 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3956465395663216850S ribosomal subunit protein L33QuickGO ontologyBLASTP
39567303957539810formamidopyrimidine DNA glycosylaseQuickGO ontologyBLASTP
39575783958057480putative enzyme of lipopolysaccharide synthesisQuickGO ontologyBLASTP
3958065395934212783-deoxy-D-manno-octulosonic-acid transferase KDO transferaseQuickGO ontologyBLASTP
395975539608131059lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
396081039619341125LPS alpha13-glucosyltransferaseQuickGO ontologyBLASTP
39619273962724798lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
396274039637561017UDP-D-galactoseglucosyllipopolysaccharide- alpha-13-D-galactosyltransferaseQuickGO ontologyBLASTP
39637733964768996lipopolysaccharide 12-glucosyltransferaseQuickGO ontologyBLASTP
39647783965470693lipopolysaccharide core biosynthesisQuickGO ontologyBLASTP
396549639665211026UDP-galactosegalactosyl LPS alpha12-galactosyltransferaseQuickGO ontologyBLASTP
39666063967589984putative beta13-glucosyltransferaseQuickGO ontologyBLASTP
396763539688881254lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
39689583969929972heptosyl transferase IQuickGO ontologyBLASTP
396993339709791047ADP-heptose--lps heptosyltransferase IIQuickGO ontologyBLASTP
39709893971921933ADP-L-glycero-D-mannoheptose-6-epimeraseQuickGO ontologyBLASTP
3972135397333111972-amino-3-ketobutyrate CoA ligaseQuickGO ontologyBLASTP
397334139743661026threonine dehydrogenaseQuickGO ontologyBLASTP
39755183976021504IS1 ORFQuickGO ontologyBLASTP
39764033977236834hypothetical proteinBLASTP
397736639786491284hypothetical proteinBLASTP
397865939802031545putative 23-bisphosphoglycerate-independent phosphoglycerate mutaseQuickGO ontologyBLASTP
39804483980879432hypothetical proteinBLASTP
39810213981272252glutaredoxin 3QuickGO ontologyBLASTP