Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:3897000 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
389708038982071128putative transporterQuickGO ontologyBLASTP
389820439008882685putative ATP-binding component of a transport system fragment 1QuickGO ontologyBLASTP
390093639020031068hypothetical proteinBLASTP
390236939039911623hypothetical proteinBLASTP
390425339058601608hypothetical proteinBLASTP
39062693907243975hypothetical proteinBLASTP
390755939087611203hypothetical proteinBLASTP
390899339104921500low-affinity phosphate transportQuickGO ontologyBLASTP
39107363911071336hypothetical proteinBLASTP
39114623911896435universal stress proteinQuickGO ontologyBLASTP
391221439136831470putative transport proteinQuickGO ontologyBLASTP
39137323914484753hypothetical proteinBLASTP
391449239165342043oligopeptidase AQuickGO ontologyBLASTP