Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:3741708 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
374170837448213114putative transport system permease proteinQuickGO ontologyBLASTP
374484637460031158hypothetical proteinBLASTP
37463423746869528hypothetical proteinBLASTP
37476683748240573hypothetical proteinBLASTP
37484953748827333hypothetical proteinBLASTP
37489313749269339hypothetical proteinBLASTP
37493333749980648putative transport ATPaseQuickGO ontologyBLASTP
37500223750552531hypothetical proteinBLASTP
37507083751307600outer membrane protein induced after carbon starvationQuickGO ontologyBLASTP
37517143752217504IS1 ORFQuickGO ontologyBLASTP
37526763753521846hypothetical proteinBLASTP
37538063754645840IS2 ORF2QuickGO ontologyBLASTP
37546693755034366IS2 ORF1QuickGO ontologyBLASTP
37552703755983714IS600 ORF2QuickGO ontologyBLASTP
37561243756426303IS600 ORF1QuickGO ontologyBLASTP
37566893757366678hypothetical proteinBLASTP
37574903758287798IS21 ORF2QuickGO ontologyBLASTP
375833837594591122IS21 ORF1QuickGO ontologyBLASTP
37595413760008468IS2 ORF2QuickGO ontologyBLASTP
37600323760397366IS2 ORF1QuickGO ontologyBLASTP
37606453760971327IS629 ORF1QuickGO ontologyBLASTP
37611863761452267IS629 ORF2QuickGO ontologyBLASTP
37614683761854387IS629 ORF2QuickGO ontologyBLASTP
37626733762975303IS600 ORF1QuickGO ontologyBLASTP