Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:3151344 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31513443152279936positive regulator for lysQuickGO ontologyBLASTP
315304431544621419low-affinity L-arabinose transport system proton symport proteinQuickGO ontologyBLASTP
315477931555407622-deoxy-D-gluconate 3-dehydrogenaseQuickGO ontologyBLASTP
31556053156441837pectin degrading enzyme 5-keto 4-deoxyuronate isomerase-like proteinQuickGO ontologyBLASTP
315672831579121185putative acyltransferaseQuickGO ontologyBLASTP
315816431593931230putative transporter proteinQuickGO ontologyBLASTP
31597933160485693hypothetical proteinBLASTP
31611423161645504IS1 ORFQuickGO ontologyBLASTP
31623853162879495hypothetical proteinBLASTP
31638833164320438hypothetical proteinBLASTP
31645983165089492hypothetical proteinBLASTP
31659713166336366IS2 ORF1QuickGO ontologyBLASTP
31663603167199840IS2 ORF2QuickGO ontologyBLASTP
316703331685201488hypothetical proteinBLASTP
3168683316875270tRNA-GlyQuickGO ontology
31688313169586756putative lipoproteinQuickGO ontologyBLASTP
317004031722982259hypothetical proteinBLASTP
31723093173187879putative dehydrogenaseQuickGO ontologyBLASTP
31731843173663480putative dehydrogenaseQuickGO ontologyBLASTP
317370331754811779putative transcriptional regulatorQuickGO ontologyBLASTP
317602931771471119putative carbamoyl transferaseQuickGO ontologyBLASTP
317720531784011197putative dehydrataseQuickGO ontologyBLASTP