Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:307013 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3070133084701458aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
308731309189459guanine-hypoxanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
3092813105251245hypothetical proteinBLASTP
310583310984402transcriptional regulator of cryptic csgA gene for curli surface fibersQuickGO ontologyBLASTP
3110233120781056outer membrane pore protein E EIcNmpABQuickGO ontologyBLASTP
3123663134691104gamma-glutamate kinaseQuickGO ontologyBLASTP
3134813147341254gamma-glutamylphosphate reductaseQuickGO ontologyBLASTP
31484931492476tRNA-ThrQuickGO ontologyBLASTP
316680317393714IS600 ORF2QuickGO ontologyBLASTP
317534317836303IS600 ORF1QuickGO ontologyBLASTP
3185883196191032IS630 ORFQuickGO ontologyBLASTP
320065320568504IS1 ORFQuickGO ontologyBLASTP
320570321541972hypothetical proteinBLASTP
321696321998303IS600 ORF1QuickGO ontologyBLASTP
322139322852714IS600 ORF2QuickGO ontologyBLASTP
32327432421894523-dihydroxyphenylpropionate 12-dioxygenaseQuickGO ontologyBLASTP
32422032588416653-3-hydroxyphenylpropionate hydroxylaseQuickGO ontologyBLASTP
3268363279181083transcriptional repressor of the lac operonQuickGO ontologyBLASTP
3280413311153075beta-D-galactosidaseQuickGO ontologyBLASTP