Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:278810 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2788102809512142unknown protein associated with Rhs elementQuickGO ontologyBLASTP
2810272852354209rhs core protein with extensionQuickGO ontologyBLASTP
285247285696450dsORF-h1QuickGO ontologyBLASTP
286237287094858putative receptor proteinQuickGO ontologyBLASTP
2883882895241137putative receptorQuickGO ontologyBLASTP
289566290336771putative amidase-type enzymeQuickGO ontologyBLASTP
290490290963474hypothetical proteinBLASTP
2910062934862481putative acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
293690294268579phosphoheptose isomeraseQuickGO ontologyBLASTP
294474295241768putative amidotransferaseQuickGO ontologyBLASTP
295212295952741hypothetical proteinBLASTP
296108296386279hypothetical proteinBLASTP
296389296649261damage-inducible protein JQuickGO ontologyBLASTP
296859297608750putative lipoproteinQuickGO ontologyBLASTP