Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:2587876 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
258787625892221347IS4 ORFQuickGO ontologyBLASTP
258946725909001434sucrose hydrolaseQuickGO ontologyBLASTP
25909082591861954sucrose operon repressorQuickGO ontologyBLASTP
25921342592352219D-serine permeaseQuickGO ontologyBLASTP
259237025936981329D-serine dehydrataseQuickGO ontologyBLASTP
259380625953441539multidrug resistance protein YQuickGO ontologyBLASTP
259534425965071164multidrug resistance protein KQuickGO ontologyBLASTP
25969232597537615putative positive transcription regulator sensor EvgSQuickGO ontologyBLASTP
259754226011353594putative sensor for regulator EvgAQuickGO ontologyBLASTP
260119126023751185putative enzymeQuickGO ontologyBLASTP
26024102603354945putative receptor proteinQuickGO ontologyBLASTP
260342426051181695putative enzymeQuickGO ontologyBLASTP
260517226064221251putative enzymeQuickGO ontologyBLASTP
26069352607558624hypothetical proteinBLASTP
26078552608130276hypothetical proteinBLASTP
26082072608449243hypothetical proteinBLASTP
26087362609722987putative heat shock proteinQuickGO ontologyBLASTP
261021426114521239putative aminotransferaseQuickGO ontologyBLASTP