Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:2251792 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
225051822517951278putative nucleoside permease proteinQuickGO ontologyBLASTP
225179222527961005hypothetical proteinBLASTP
22527932253758966putative kinaseQuickGO ontologyBLASTP
22537322254478747putative transcriptional regulatorQuickGO ontologyBLASTP
22545302255357828hypothetical proteinBLASTP
22554132256213801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
22562102256998789hydoxyethylthiazole kinaseQuickGO ontologyBLASTP
22572212257493273hypothetical proteinBLASTP
22576142258438825hypothetical proteinBLASTP
22584772258995519hypothetical proteinBLASTP
225907722601111035putative type-1 fimbrial proteinQuickGO ontologyBLASTP
22622122262715504IS1 ORFQuickGO ontologyBLASTP
22634002264119720putative chaperoneQuickGO ontologyBLASTP
22641542264696543putative fimbrial-like proteinQuickGO ontologyBLASTP
22649392265220282hypothetical proteinBLASTP
226546522666041140putative ATPaseQuickGO ontologyBLASTP
226670622687392034methionine tRNA synthetaseQuickGO ontologyBLASTP
22688802269701822molybdate metabolism regulator first fragmentQuickGO ontologyBLASTP
22696362270139504IS1 ORFQuickGO ontologyBLASTP
227243422744342001hypothetical proteinBLASTP