Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:2007467 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20074672007865399hypothetical proteinBLASTP
20079052008624720TonBQuickGO ontologyBLASTP
200871520102351521hypothetical bacteriophage proteinQuickGO ontologyBLASTP
20111322011971840IS2 ORF2QuickGO ontologyBLASTP
20125482012982435hypothetical protein
20129942013707714IS600 ORF2QuickGO ontologyBLASTP
20138482014150303IS600 ORF1QuickGO ontologyBLASTP
201472520157561032IS630 ORFQuickGO ontologyBLASTP
201576220170391278hypothetical proteinBLASTP
20174282018138711hypothetical proteinBLASTP
20186542018869216hypothetical proteinBLASTP
20189142019417504IS1 ORFQuickGO ontologyBLASTP
20206872021244558hypothetical proteinBLASTP
20228072023358552putative resolvaseQuickGO ontologyBLASTP
20240612024453393hypothetical proteinBLASTP
20245552025268714IS600 ORF2QuickGO ontologyBLASTP
20254092025711303IS600 ORF1QuickGO ontologyBLASTP
202602020272731254putative potassium channel proteinQuickGO ontologyBLASTP
202764420291041461cardiolipin synthase a major membrane phospholipid novobiocin sensitivityQuickGO ontologyBLASTP
20290612029468408hypothetical proteinBLASTP
202952120305251005ATP-binding protein of oligopeptide ABC transport systemQuickGO ontologyBLASTP
203052220315351014ATP-binding protein of oligopeptide ABC transport systemQuickGO ontologyBLASTP
20315472032455909oligopeptide transport permease protein-like proteinQuickGO ontologyBLASTP
20324702033390921oligopeptide transport permease proteinQuickGO ontologyBLASTP
203347620351071632oligopeptide transport periplasmic binding proteinQuickGO ontologyBLASTP
20358452036492648putative channel proteinQuickGO ontologyBLASTP
203697020396452676CoA-linked acetaldehyde dehydrogenase and iron-dependent alcohol dehydrogenase pyruvate-formate-lyase deactivaseQuickGO ontologyBLASTP