Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:1763375 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17626531763387735hypothetical proteinBLASTP
17633751763725351hypothetical proteinBLASTP
176392817650641137putative receptorQuickGO ontologyBLASTP
17656451766148504IS1 ORFQuickGO ontologyBLASTP
17670791767834756putative transposase subunitQuickGO ontologyBLASTP
176785117693861536putative transposaseQuickGO ontologyBLASTP
17695821769866285ISSfl2 ORFQuickGO ontologyBLASTP
17700451770461417ISSfl2 ORFQuickGO ontologyBLASTP
177108217748853804rhs core protein with extensionQuickGO ontologyBLASTP
17751431776138996H-repeat-associated protein-like proteinQuickGO ontologyBLASTP
177663917799083270rhs core protein with extensionQuickGO ontologyBLASTP
17801311780601471unknown protein associated with Rhs elementQuickGO ontologyBLASTP
178070217828102109unknown protein associated with Rhs elementQuickGO ontologyBLASTP