Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:16500 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1702817855828putative transposaseQuickGO ontologyBLASTP
17921190931173IS21 ORF1QuickGO ontologyBLASTP
1909319890798IS21 ORF2QuickGO ontologyBLASTP
1990020289390hypothetical proteinBLASTP
20572217381167NaH antiporter pH dependentQuickGO ontologyBLASTP
2179822703906transcriptional activator of nhaAQuickGO ontologyBLASTP
2274123424684hypothetical proteinBLASTP
2371424517804hypothetical proteinBLASTP
2475325256504IS1 ORFQuickGO ontologyBLASTP
2526725635369hypothetical proteinBLASTP
26076271971122hypothetical proteinBLASTP
279812824426430S ribosomal subunit protein S20QuickGO ontologyBLASTP
2834728565219hypothetical proteinBLASTP
2857329514942putative regulatorQuickGO ontologyBLASTP
29557323732817isoleucine tRNA synthetaseQuickGO ontologyBLASTP
3237332867495prolipoprotein signal peptidaseQuickGO ontologyBLASTP
3299233441450probable FKBX-type 16KD peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
3344334393951control of stringent responseQuickGO ontologyBLASTP
3445935373915hypothetical proteinBLASTP
3554036361822dihydrodipicolinate reductaseQuickGO ontologyBLASTP
36817379651149carbamoyl-phosphate synthetase glutamine small subunitQuickGO ontologyBLASTP
37983412043222carbamoyl-phosphate synthase large subunitQuickGO ontologyBLASTP