Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:1355060 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
135506013560701011Holliday junction helicase subunit AQuickGO ontologyBLASTP
13562171357002786hypothetical proteinBLASTP
13569991357754756putative ATP-binding component of a transport systemQuickGO ontologyBLASTP
13577791358765987putative adhesinQuickGO ontologyBLASTP
135884413601031260hypothetical proteinBLASTP
13602231361194972suppressor of htrB heat shock proteinQuickGO ontologyBLASTP
136141413627091296hypothetical proteinBLASTP
13627551363258504IS1 ORFQuickGO ontologyBLASTP
136348113651331653putative alpha-mannosidaseQuickGO ontologyBLASTP
136517013670381869hypothetical proteinBLASTP
13671271367366240hypothetical proteinBLASTP
13676821368185504IS1 ORFQuickGO ontologyBLASTP
13683061369148843hypothetical proteinBLASTP
136920813706501443glucose-stimulated pyruvate kinase IIQuickGO ontologyBLASTP
13707781371647870hypothetical proteinBLASTP
137198513734601476glucose-6-phosphate dehydrogenaseQuickGO ontologyBLASTP
1373695137550618126-phosphogluconate dehydrataseQuickGO ontologyBLASTP
137554313761846422-keto-3-deoxygluconate 6-phosphate aldolase2-keto-4-hydroxyglutarate aldolaseQuickGO ontologyBLASTP
137624013774181179phosphoribosylglycinamide formyltransferase 2QuickGO ontologyBLASTP
13775521377842291hypothetical proteinBLASTP
13778971378265369hypothetical proteinBLASTP
13785921379251660hypothetical proteinBLASTP
137945913815192061protease IIQuickGO ontologyBLASTP
13815161382178663hypothetical proteinBLASTP