Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:1320287 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
132028713213871101putative cytochrome C-type proteinQuickGO ontologyBLASTP
13215781321880303IS600 ORF1QuickGO ontologyBLASTP
13220211322734714IS600 ORF2QuickGO ontologyBLASTP
132281713251082292biotin sulfoxide reductase 2QuickGO ontologyBLASTP
13252731326244972putative enzymeQuickGO ontologyBLASTP
13262411326984744hypothetical proteinBLASTP
13270251327450426hypothetical proteinBLASTP
13284071328958552putative resolvaseQuickGO ontologyBLASTP
13308681331242375hypothetical proteinBLASTP
13341461334448303IS600 ORF1QuickGO ontologyBLASTP
13345891335302714IS600 ORF2QuickGO ontologyBLASTP
13352991335487189hypothetical proteinBLASTP
1336980133705677tRNA-ArgQuickGO ontologyBLASTP
1337157133723276tRNA-MetQuickGO ontologyBLASTP
13373351338189855antitermination protein QQuickGO ontologyBLASTP
13381861338560375putative crossover junction endodeoxyribonucleaseQuickGO ontologyBLASTP
13385601338817258putative bacteriophage proteinQuickGO ontologyBLASTP
13391521339949798IS21 ORF2QuickGO ontologyBLASTP
133994913411211173IS21 ORF1QuickGO ontologyBLASTP
13411401341412273IS2 ORF1QuickGO ontologyBLASTP
13414361342275840IS2 ORF2QuickGO ontologyBLASTP
13423921342694303IS600 ORF1QuickGO ontologyBLASTP
13428571343360504IS1 ORFQuickGO ontologyBLASTP
13436121344325714IS600 ORF2QuickGO ontologyBLASTP
13443531345306954putative phage tail fiber proteinQuickGO ontologyBLASTP
13452571345880624hypothetical bacteriophage proteinQuickGO ontologyBLASTP
134606013478111752invasion plasmid antigenQuickGO ontologyBLASTP