Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:1086025 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
108602510872661242periplasmic glucose-1-phosphataseQuickGO ontologyBLASTP
10873041087531228hypothetical proteinBLASTP
10875521088157606trp repressor binding proteinQuickGO ontologyBLASTP
10890931089932840IS2 ORF2QuickGO ontologyBLASTP
108994410911881245hypothetical proteinBLASTP
10913121092067756putative transposase subunitQuickGO ontologyBLASTP
109208410936191536putative transposaseQuickGO ontologyBLASTP
109470110968812181hypothetical proteinBLASTP
10972111097921711hypothetical proteinBLASTP
11001951101148954hypothetical proteinBLASTP
11016671102191525putative DNA methylaseQuickGO ontologyBLASTP
11038411104071231hypothetical proteinBLASTP
110443511058291395putative transport proteinQuickGO ontologyBLASTP
11057841106242459hypothetical proteinBLASTP
11062891106879591putative enzymeQuickGO ontologyBLASTP
11068891107689801putative acetyltransferaseQuickGO ontologyBLASTP
11088711109605735putative synthetaseQuickGO ontologyBLASTP
11101911110694504IS1 ORFQuickGO ontologyBLASTP
11117191112357639putative tet operon regulatorQuickGO ontologyBLASTP
111239711163593963proline dehydrogenase P5C dehydrogenaseQuickGO ontologyBLASTP