Pre_GI Gene

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Host: NC_007323 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007323:1 Bacillus anthracis str. 'Ames Ancestor' plasmid pXO2, complete

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5431139597hypothetical proteinBLASTP
11511438288hypothetical proteinBLASTP
16521768117hypothetical proteinBLASTP
17462594849hypothetical proteinBLASTP
25912866276hypothetical proteinBLASTP
29553563609hypothetical proteinBLASTP
358947311143nlpp60 family protein pxo2-08QuickGO ontologyBLASTP
473366671935hypothetical proteinBLASTP
66847358675hypothetical proteinBLASTP
74167730315hypothetical proteinBLASTP
77337936204hypothetical proteinBLASTP
79388192255hypothetical proteinBLASTP
8210110682859membrane protein putative pxo2-14QuickGO ontologyBLASTP
1106811886819hypothetical proteinBLASTP
11888137231836conjugation protein tragtrad family pxo2-16QuickGO ontologyBLASTP