Pre_GI Gene

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Host: NC_007322 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007322:57710 Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, complete

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
57710590171308hypothetical proteinBLASTP
5904559395351hypothetical proteinBLASTP
5998160586606hypothetical proteinBLASTP
6077861005228hypothetical proteinBLASTP
614046149996hypothetical protein
6194662059114hypothetical protein
62244633801137hypothetical proteinBLASTP
6339663518123hypothetical protein
6409065043954hypothetical proteinBLASTP
65063665411479hypothetical proteinBLASTP
6655867007450hypothetical proteinBLASTP
6703367428396hypothetical proteinBLASTP
67652688661215surface layer protein pxo1-54QuickGO ontologyBLASTP
69021713722352hypothetical proteinBLASTP
7150471665162hypothetical proteinBLASTP
7184872078231hypothetical proteinBLASTP
7240873013606hypothetical proteinBLASTP
7328474102819hypothetical proteinBLASTP
74119755521434bacterial type iiiv secretion system protein pxo1-59QuickGO ontologyBLASTP
7554576477933membrane protein putative pxo1-60QuickGO ontologyBLASTP
7650077189690hypothetical proteinBLASTP
7717377346174hypothetical proteinBLASTP
7738977592204hypothetical proteinBLASTP
7766577871207hypothetical proteinBLASTP
7794378548606hypothetical proteinBLASTP
78619797041086hypothetical proteinBLASTP
79735814831749hypothetical proteinBLASTP
8138081664285hypothetical proteinBLASTP
8170382248546hypothetical proteinBLASTP
8232682733408hypothetical proteinBLASTP
8276082867108hypothetical proteinBLASTP
8360684070465hypothetical proteinBLASTP
84349856621314hypothetical proteinBLASTP
857028580099hypothetical protein
8580086696897hypothetical proteinBLASTP
8678287051270hypothetical proteinBLASTP
8729787494198hypothetical proteinBLASTP
8769588030336hypothetical proteinBLASTP
8809788447351hypothetical proteinBLASTP
8844889362915hypothetical proteinBLASTP
91495951633669membrane protein putative pxo1-79QuickGO ontologyBLASTP