Pre_GI Gene

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Host: NC_006369 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006369:734080 Legionella pneumophila str. Lens, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7340807354051326ATP-dependent protease ATP-binding subunitQuickGO ontologyBLASTP
7356057371791575hypothetical proteinBLASTP
7373297385671239hypothetical proteinBLASTP
762959763558600hypothetical proteinBLASTP
763740764090351hypothetical proteinBLASTP
764146764928783hypothetical proteinBLASTP
764921765691771hypothetical proteinBLASTP
76582876605522850S ribosomal protein L31QuickGO ontologyBLASTP
7661827674171236hypothetical proteinBLASTP
7676277689191293hypothetical proteinBLASTP
7689007701771278hypothetical proteinBLASTP