Pre_GI Gene

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Host: NC_006369 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006369:3058000 Legionella pneumophila str. Lens, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
30581433058805663hypothetical protein
305910030603651266hypothetical proteinBLASTP
30605153061051537Inorganic pyrophosphataseQuickGO ontologyBLASTP
30611813061522342hypothetical proteinBLASTP
30615343062073540GTP cyclohydrolase IQuickGO ontologyBLASTP
306213230632231092hypothetical proteinBLASTP
306335830655472190Polynucleotide phosphorylase PNPaseQuickGO ontologyBLASTP
30660853066996912tRNA pseudouridine synthase BQuickGO ontologyBLASTP
30669833067354372Ribosome-binding factor AQuickGO ontologyBLASTP
306735830699642607translation initiation factor IF-2QuickGO ontologyBLASTP
307005330715311479transcription elongation factor NusAQuickGO ontologyBLASTP
30715433072001459hypothetical proteinBLASTP
307373830752431506NADH-quinone oxidoreductase chain MQuickGO ontologyBLASTP
307525930772321974NADH-quinone oxidoreductase chain LQuickGO ontologyBLASTP
30772373077542306NADH-quinone oxidoreductase chain KQuickGO ontologyBLASTP
30775603078219660NADH-quinone oxidoreductase chain JQuickGO ontologyBLASTP
30782313078731501NADH dehydrogenase subunit IQuickGO ontologyBLASTP
307875030797721023NADH-quinone oxidoreductase chain HQuickGO ontologyBLASTP