Pre_GI Gene

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Host: NC_006369 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006369:2338000 Legionella pneumophila str. Lens, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
233804523394931449hypothetical proteinBLASTP
233959023408491260hypothetical proteinBLASTP
23409372341296360hypothetical proteinBLASTP
234515123497554605SdeC protein substrate of the DotIcm systemQuickGO ontologyBLASTP
234997023510911122hypothetical proteinBLASTP
235114423537682625hypothetical proteinBLASTP
235404623598085763substrates of the Legionella pneumophila DotIcm system SdeBQuickGO ontologyBLASTP