Pre_GI Gene

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Host: NC_006368 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006368:3211998 Legionella pneumophila str. Paris, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain is endemic in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
321199832134761479transcription elongation factor NusAQuickGO ontologyBLASTP
32134883213946459hypothetical proteinBLASTP
321568332171881506NADH-quinone oxidoreductase chain MQuickGO ontologyBLASTP
321720432191771974NADH-quinone oxidoreductase chain LQuickGO ontologyBLASTP
32191823219487306NADH-quinone oxidoreductase chain KQuickGO ontologyBLASTP
32195053220164660NADH-quinone oxidoreductase chain JQuickGO ontologyBLASTP
32201763220676501NADH dehydrogenase subunit IQuickGO ontologyBLASTP
322069532217171023NADH-quinone oxidoreductase chain HQuickGO ontologyBLASTP
322173032240812352NADH dehydrogenase gamma subunitQuickGO ontologyBLASTP
322409832253751278NADH dehydrogenase I chain FQuickGO ontologyBLASTP
32253943225861468NADH dehydrogenase I chain EQuickGO ontologyBLASTP
322595832272111254NADH dehydrogenase delta subunitQuickGO ontologyBLASTP
32272043227887684NADH dehydrogenase I chain CQuickGO ontologyBLASTP
32279103228386477NADH dehydrogenase beta subunitQuickGO ontologyBLASTP
32286333228989357NADH dehydrogenase I chain AQuickGO ontologyBLASTP
32291693229492324Protein-export membrane protein secG Preprotein translocase subunitQuickGO ontologyBLASTP