Pre_GI Gene

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Host: NC_006368 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006368:2684358 Legionella pneumophila str. Paris, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain is endemic in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
268435826875523195hypothetical proteinBLASTP
26874712687998528hypothetical proteinBLASTP
26881442688350207hypothetical protein
26902672690590324hypothetical proteinBLASTP
26907292691193465Chemiosmotic efflux system C protein AQuickGO ontologyBLASTP
26943942695362969Chemiosmotic efflux system C protein BQuickGO ontologyBLASTP
269535926966721314Chemiosmotic efflux system C protein CQuickGO ontologyBLASTP
26966972697056360hypothetical proteinBLASTP
26972082698089882hypothetical proteinBLASTP
269822827004382211hypothetical proteinBLASTP
27006942701617924phosphoribosylpyrophosphate synthetaseQuickGO ontologyBLASTP
270160227031551554putative thymidine phosphorylaseQuickGO ontologyBLASTP
270311327045251413hypothetical proteinBLASTP
270447127076143144Chemiosmotic efflux system B protein AQuickGO ontologyBLASTP
270768927088221134Chemiosmotic efflux system B protein BQuickGO ontologyBLASTP
270881927100781260Chemiosmotic efflux system B protein CQuickGO ontologyBLASTP
271006527127552691hypothetical proteinBLASTP