Pre_GI Gene

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Host: NC_006085 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006085:481231 Propionibacterium acnes KPA171202, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4812314836542424cobyrinic acid ac-diamide synthaseQuickGO ontologyBLASTP
483664484440777uroporphyrinogen III methyltransferaseQuickGO ontologyBLASTP
4844604855001041precorrin-6x reductaseQuickGO ontologyBLASTP
4854394871061668phosphoribosyltransferase cobalamin biosynthesis enzyme fusion CobTUQuickGO ontologyBLASTP
487055487942888putative cobalamin-5-phosphate synthase CobSQuickGO ontologyBLASTP
487939488703765metal binding proteinQuickGO ontologyBLASTP
48876048883879tRNA-ThrQuickGO ontologyBLASTP
4889254905621638hypothetical proteinBLASTP
490993491181189hypothetical protein
4912194928081590ascorbate-specific PTS system enzyme IICQuickGO ontologyBLASTP
492858493787930phosphotransferase system protein mannitolfructose-specific IIA subunitQuickGO ontologyBLASTP
494686495183498hypothetical protein
495192495638447hypothetical membrane proteinQuickGO ontologyBLASTP
495789496271483S-ribosylhomocysteinaseQuickGO ontologyBLASTP
4963094974901182phosphomannose isomeraseQuickGO ontologyBLASTP
497535497819285hypothetical proteinBLASTP
4981524997861635chaperonin GroELQuickGO ontologyBLASTP
4999215009971077transaldolaseQuickGO ontologyBLASTP
501099501842744GntR-family transcriptional regulatorQuickGO ontologyBLASTP
502057503046990carbohydrate kinaseQuickGO ontologyBLASTP
5028905039301041hypothetical proteinBLASTP
503927504799873putative myo-inositol catabolism protein IolBQuickGO ontologyBLASTP