Pre_GI Gene

Some Help

Host: NC_006085 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006085:1859191 Propionibacterium acnes KPA171202, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18591911860030840putative BirA bifunctional proteinQuickGO ontologyBLASTP
18601621860533372hypothetical proteinBLASTP
186062618622001575propionyl-CoA carboxylase beta chainQuickGO ontologyBLASTP
18622121862427216hypothetical proteinBLASTP
18624051863070666Maf-like proteinQuickGO ontologyBLASTP
18636451864064420hypothetical proteinBLASTP
18642611864995735short chain dehydrogenaseQuickGO ontologyBLASTP
18650991866004906phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
186806318694631401hypothetical proteinBLASTP
18696631870661999putative magnesium transport proteinQuickGO ontologyBLASTP
18706581871059402conserved protein putative ADP-ribose pyrophosphataseQuickGO ontologyBLASTP
18711321871389258hypothetical protein
187142518731941770putative biotin-dependent acetylpropionyl-CoA acyl-CoA carboxylaseQuickGO ontologyBLASTP
18732901873976687hypothetical proteinBLASTP
187401518753941380dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
18755821876394813purine nucleoside phosphorylaseQuickGO ontologyBLASTP
187642118780971677phosphoglucomutasephosphomannomutaseQuickGO ontologyBLASTP
187812918798021674putative fatty acid--CoA ligase AMP-binding enzymeQuickGO ontologyBLASTP
18799891880642654putative uridine kinaseQuickGO ontologyBLASTP