Pre_GI Gene

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Host: NC_006085 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006085:15246 Propionibacterium acnes KPA171202, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1524616214969L-lactate dehydrogenaseQuickGO ontologyBLASTP
1641216606195hypothetical protein
16732177391008putative transcriptional regulatorQuickGO ontologyBLASTP
17736192411506ABC transporter proteinQuickGO ontologyBLASTP
1932420301978ribose ABC transporterQuickGO ontologyBLASTP
2035021291942periplasmic sugar-binding proteinQuickGO ontologyBLASTP
2128822217930sugar kinaseQuickGO ontologyBLASTP
2221422597384high affinity ribose transport protein RbsDQuickGO ontologyBLASTP
2278023049270hypothetical proteinBLASTP
2320123677477PTS system galactitol-specific IIA componentQuickGO ontologyBLASTP
23734249901257PTS system galactitol-specific IIC componentQuickGO ontologyBLASTP
2501125313303PTS system galactitol-specific IIB componentQuickGO ontologyBLASTP
2530325686384alcohol dehydrogenaseQuickGO ontologyBLASTP
2842728711285hypothetical protein
2871829083366hypothetical protein
2931329984672hypothetical proteinBLASTP
3000830586579putative phosphataseQuickGO ontologyBLASTP
3078431542759transcriptional regulatorQuickGO ontologyBLASTP
3173032152423hypothetical protein
3215832895738hypothetical proteinBLASTP
3288933428540hypothetical protein
33561346191059putative aminotransferaseQuickGO ontologyBLASTP
3555236118567acetyltransferaseQuickGO ontologyBLASTP
3613236791660hypothetical proteinBLASTP
3704437682639hypothetical proteinBLASTP
3768238500819hypothetical proteinBLASTP
38497399751479secretion system proteinQuickGO ontologyBLASTP
3996640847882membrane spanning proteinQuickGO ontologyBLASTP
4084041742903membrane associated proteinQuickGO ontologyBLASTP
4173942401663hypothetical protein
4239842907510hypothetical proteinBLASTP
42904456662763hypothetical membrane-spanning proteinQuickGO ontologyBLASTP