Pre_GI Gene

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Host: NC_006085 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006085:1234587 Propionibacterium acnes KPA171202, complete genome

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolated from human skin. Acne causing bacterium. This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic.It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
123007712345944518large subunit of NADH-dependent glutamate synthaseQuickGO ontologyBLASTP
123458712360591473glutamate synthase small subunitQuickGO ontologyBLASTP
12360961236425330hypothetical protein
123647712385492073hypothetical proteinBLASTP
12387281239123396hypothetical proteinBLASTP
12391481239375228hypothetical proteinBLASTP
12393851240257873putative transcriptional regulatorQuickGO ontologyBLASTP
12403831241297915hypothetical proteinBLASTP
124127512428341560PTS system sucrose-specific IIBC componentQuickGO ontologyBLASTP
12428411243284444hypothetical proteinBLASTP
12432741244209936putative N-acetylglucosamine kinaseQuickGO ontologyBLASTP
124421212452161005hypothetical proteinBLASTP
124521312466431431beta-glucosidaseQuickGO ontologyBLASTP
12466711246982312PTS system lichenan-specific IIB componentQuickGO ontologyBLASTP
124698812482561269PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
12482981248618321PTS cellobiose-specific component IIAQuickGO ontologyBLASTP
12490661249416351hypothetical protein
124942312530853663DNA polymerase III subunit alphaQuickGO ontologyBLASTP
12530821253636555hypothetical membrane spanning proteinQuickGO ontologyBLASTP
125364112549601320histidinol dehydrogenaseQuickGO ontologyBLASTP
125495712561231167histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
12561201256740621imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
12566971257350654imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
125736312581307681-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneamino imidazole-4-carboxamide isomeraseQuickGO ontologyBLASTP
12582801259074795hypothetical proteinBLASTP
12590711259661591Holliday junction resolvaseQuickGO ontologyBLASTP
12596581260263606holliday junction DNA helicase RuvAQuickGO ontologyBLASTP