Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:196976 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1969762021565181Surface proteinBartonella adhesinQuickGO ontologyBLASTP
204160204621462Surface proteinQuickGO ontologyBLASTP
2053782144889111Surface proteinBartonella adhesinQuickGO ontologyBLASTP
214443214646204Surface proteinQuickGO ontologyBLASTP
214664215236573hypothetical proteinBLASTP
2161492174591311ExopolyphosphataseQuickGO ontologyBLASTP
217493218236744Cell division protein ftsJQuickGO ontologyBLASTP
2192092202311023GTP-binding proteinQuickGO ontologyBLASTP
2202372213761140gamma-glutamyl kinaseQuickGO ontologyBLASTP
2214442226821239Gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP