Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1888500 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18886211889364744hypothetical proteinBLASTP
18894021890358957acetyl-CoA carboxylase alpha subunitQuickGO ontologyBLASTP
18904321891370939Integrase recombinase xerDQuickGO ontologyBLASTP
18916291892261633Shikimate kinaseQuickGO ontologyBLASTP
1892236189336911343-dehydroquinate synthaseQuickGO ontologyBLASTP
18934301893738309tRNA-ArgQuickGO ontology
18937821894177396hypothetical proteinBLASTP
18941951894587393hypothetical proteinBLASTP
18946051895015411pH adaptation potassium efflux system gQuickGO ontologyBLASTP
18950121895293282pH adaptation potassium efflux system fQuickGO ontologyBLASTP
18952901895775486pH adaptation potassium efflux system eQuickGO ontologyBLASTP
189577218973941623NADH dehydrogenase subunit NQuickGO ontologyBLASTP
18973941897735342hypothetical proteinBLASTP
189773519006562922pH adaptation potassium efflux system transmembrane proteinQuickGO ontologyBLASTP
19008461901331486Transmembrane proteinQuickGO ontologyBLASTP
190150019025971098Carboxynorspermidine decarboxylaseQuickGO ontologyBLASTP
190265419038861233hypothetical proteinBLASTP
19055001905892393hypothetical protein