Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1648000 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
164952916508241296UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
16509761651167192hypothetical protein
1651308165138275tRNA-ThrQuickGO ontology
16525961653312717phage related proteinQuickGO ontologyBLASTP
16548721655069198hypothetical proteinBLASTP
16550751655464390hypothetical proteinBLASTP
16557781656095318hypothetical proteinBLASTP
16566501657579930hypothetical proteinBLASTP
16575761657869294hypothetical proteinBLASTP
165785316589981146hypothetical proteinBLASTP
165898216617412760phage related proteinQuickGO ontologyBLASTP
16632831663849567hypothetical proteinBLASTP
16692161669407192hypothetical protein
16713991671683285hypothetical proteinBLASTP
16730331673446414hypothetical protein