Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1616804 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
161496616168191854hypothetical proteinBLASTP
161680416180121209phage related proteinQuickGO ontologyBLASTP
16181151618564450hypothetical protein
16185451618874330hypothetical proteinBLASTP
16189961619289294hypothetical protein
161987416224532580ATP-dependent clp protease ATP-binding subunit clpBQuickGO ontologyBLASTP
16237181624002285zinc-binding proteinQuickGO ontologyBLASTP
16240161624714699Septum formation maf proteinQuickGO ontologyBLASTP
16249101625128219translation initiation factor IF-1QuickGO ontologyBLASTP
16253651626306942hypothetical proteinBLASTP
16263741626760387Transcriptional regulatorQuickGO ontologyBLASTP
16268271627057231hypothetical protein
16300791630660582hypothetical proteinBLASTP
16306711630823153hypothetical protein
16309371631227291hypothetical protein
16311951631356162hypothetical protein
16314031632176774hypothetical proteinBLASTP
16322441632570327Transcriptional regulatorQuickGO ontologyBLASTP
16328651633209345hypothetical proteinBLASTP
16334891633863375hypothetical protein
16351651635392228Virulence-associated proteinQuickGO ontologyBLASTP