Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:152497 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
152497153252756Heme exporter protein CQuickGO ontologyBLASTP
153299153964666Heme exporter protein BQuickGO ontologyBLASTP
153961154587627Heme exporter protein AQuickGO ontologyBLASTP
1548891575762688aconitate hydrataseQuickGO ontologyBLASTP
15780015806626730S ribosomal protein S20QuickGO ontologyBLASTP
1587711603421572chromosomal replication initiation proteinQuickGO ontologyBLASTP
1605391616601122DNA polymerase III subunit betaQuickGO ontologyBLASTP
1616811628141134recombination protein FQuickGO ontologyBLASTP
1628621633084473-dehydroquinate dehydrataseQuickGO ontologyBLASTP
163432164403972Cytochrome o ubiquinol oxidase subunit IIQuickGO ontologyBLASTP
1644781664962019Cytochrome o ubiquinol oxidase subunit IQuickGO ontologyBLASTP
166493167158666Cytochrome o ubiquinol oxidase subunit IIIQuickGO ontologyBLASTP
167158167844687Cytochrome o ubiquinol oxidase subunit IVQuickGO ontologyBLASTP
1682831693051023NADPH-dependent glycerol-3-phosphate dehydrogenaseQuickGO ontologyBLASTP
169588170406819enoyl-acyl carrier protein reductaseQuickGO ontologyBLASTP
17045517167512213-oxoacyl-acyl carrier protein synthaseQuickGO ontologyBLASTP