Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1455496 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
145549614565241029hypothetical proteinBLASTP
14565351457506972hypothetical proteinBLASTP
14583091458431123BLASTP
14592851459866582Probable surface proteinQuickGO ontologyBLASTP
145986314623462484hypothetical proteinBLASTP
146306414690906027Probable surface proteinQuickGO ontologyBLASTP
14703311471284954BLASTP
14712321472220989BLASTP
14721781472962785
1473065147313874tRNA-GlnQuickGO ontology
14731841473395212BLASTP
147450114755051005hypothetical proteinBLASTP