Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1111500 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
111185011130641215isocitrate dehydrogenaseQuickGO ontologyBLASTP
111318111146081428Transport transmembrane proteinQuickGO ontologyBLASTP
111465311158431191Transport transmembrane proteinQuickGO ontologyBLASTP
111664011177581119queuine tRNA-ribosyltransferaseQuickGO ontologyBLASTP
11189221119434513Peptidyl prolyl cis-trans isomerase bQuickGO ontologyBLASTP
11194571120029573Peptidyl-prolyl cis-trans isomerase bQuickGO ontologyBLASTP
11200191120552534phosphopantetheine adenylyltransferaseQuickGO ontologyBLASTP
112056211233572796DNA gyrase subunit AQuickGO ontologyBLASTP
11235901124108519Single-strand binding protein ssbQuickGO ontologyBLASTP
112444911273642916excinuclease ABC subunit AQuickGO ontologyBLASTP
11276411127979339Nitrogen regulatory protein p-IIQuickGO ontologyBLASTP
112803611294451410Glutamine synthetase IQuickGO ontologyBLASTP