Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:674337 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
674337675242906oligopeptide ABC transporter permease proteinQuickGO ontologyBLASTP
675261676229969oligopeptide ABC transporter permease proteinQuickGO ontologyBLASTP
676244677170927oligopeptide ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
677157678104948ABC transporter nucleotide binding domainQuickGO ontologyBLASTP
6782846796331350glycerol-3-phosphate transporterQuickGO ontologyBLASTP
679906680364459transcriptional regulator MarR familyQuickGO ontologyBLASTP
6803846818141431multidrug-efflux transporterQuickGO ontologyBLASTP
682122683093972ribose operon repressorQuickGO ontologyBLASTP
683107684003897ribokinaseQuickGO ontologyBLASTP
684000684395396ribose ABC transporter proteinQuickGO ontologyBLASTP
6844146858981485ribose ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
685901686836936ribose ABC transporter permease proteinQuickGO ontologyBLASTP
686851687777927ribose ABC transporter ribose-binding proteinQuickGO ontologyBLASTP
687812688459648transaldolaseQuickGO ontologyBLASTP
6887766911752400immune inhibitor A metalloproteaseQuickGO ontologyBLASTP
691494691835342hypothetical proteinBLASTP
6918736930451173multidrug resistance protein putativeQuickGO ontologyBLASTP