Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:5202176 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
52021765202970795metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
52029545203796843yycI proteinQuickGO ontologyBLASTP
520377752050931317YycH proteinQuickGO ontologyBLASTP
520509052069311842sensory box histidine kinase YycGQuickGO ontologyBLASTP
52069355207642708DNA-binding response regulator YycFQuickGO ontologyBLASTP
5208043520811876tRNA-PheQuickGO ontologyBLASTP
5208253520832775tRNA-GluQuickGO ontologyBLASTP
5208338520841679tRNA-LysQuickGO ontologyBLASTP
520855652098451290adenylosuccinate synthetaseQuickGO ontologyBLASTP
521006152114221362replicative DNA helicaseQuickGO ontologyBLASTP
5211450521189644750S ribosomal protein L9QuickGO ontologyBLASTP
521189352138661974DHH subfamily 1 proteinQuickGO ontologyBLASTP
52139455214883939hypothetical proteinBLASTP
5214961521519423430S ribosomal protein S18QuickGO ontologyBLASTP
52152405215761522single-strand DNA-binding proteinQuickGO ontologyBLASTP
5215788521607829130S ribosomal protein S6QuickGO ontologyBLASTP
521627052173701101GTP-binding protein YchFQuickGO ontologyBLASTP
52174865217683198hypothetical proteinBLASTP
52177045218585882mechanosensitive ion channel family proteinQuickGO ontologyBLASTP
52188455219441597hypothetical proteinBLASTP
52194625220313852stage 0 sporulation protein JQuickGO ontologyBLASTP
52203065221067762sporulation initiation inhibitor protein SojQuickGO ontologyBLASTP
52212585222130873stage 0 sporulation protein J putativeQuickGO ontologyBLASTP
52222355222954720glucose-inhibited division protein BQuickGO ontologyBLASTP
522297652248651890glucose-inhibited division protein AQuickGO ontologyBLASTP