Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:5053000 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
50531495053493345hypothetical proteinBLASTP
50536585054206549hypothetical proteinBLASTP
505428450553241041sua5yciOyrdCywlC family proteinQuickGO ontologyBLASTP
50554335055891459hypothetical proteinBLASTP
50559415056807867stage II sporulation protein R putativeQuickGO ontologyBLASTP
50569205057771852modification methylase HemK familyQuickGO ontologyBLASTP
505777150588471077peptide chain release factor 1QuickGO ontologyBLASTP
50591095059693585thymidine kinaseQuickGO ontologyBLASTP
5059802506004724650S ribosomal protein L31QuickGO ontologyBLASTP
506045150617221272transcription termination factor RhoQuickGO ontologyBLASTP
50620655063030966fructose-16-bisphosphatase class IIQuickGO ontologyBLASTP
506314850644371290UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50647695065626858fructose-bisphosphate aldolaseQuickGO ontologyBLASTP
50658375066205369stage 0 sporulation protein FQuickGO ontologyBLASTP
50664075066931525hypothetical proteinBLASTP
506696350685701608CTP synthetaseQuickGO ontologyBLASTP
50688285069355528DNA-directed RNA polymerase delta subunitQuickGO ontologyBLASTP
50695105070139630transcriptional regulator TetR familyQuickGO ontologyBLASTP
507020450713431140acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
507136550724951131acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
507256950734208523-hydroxybutyryl-CoA dehydrogenaseQuickGO ontologyBLASTP
507347050746511182acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP