Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:5011857 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
501063250119061275glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
501185750130981242glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
501339250143931002mbl proteinQuickGO ontologyBLASTP
50145555014953399stage III sporulation protein DQuickGO ontologyBLASTP
50152325015612381lipoprotein putativeQuickGO ontologyBLASTP
50160445016949906stage II sporulation proteinQuickGO ontologyBLASTP
50171115017815705ABC transporter permease protein putativeQuickGO ontologyBLASTP
50178155018657843ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
50188395019252414ABC transporter ATP-binding protein C-terminusQuickGO ontologyBLASTP
50193375019846510ABC transporter ATP-binding protein N-terminusQuickGO ontologyBLASTP
501997450209931020stage II sporulation protein DQuickGO ontologyBLASTP
502120150225051305UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
50225455023255711hypothetical proteinBLASTP
50233015023537237hypothetical proteinBLASTP
502390350254231521NADH dehydrogenase subunit NQuickGO ontologyBLASTP
502542550269181494NADH dehydrogenase subunit MQuickGO ontologyBLASTP
502691550287771863NADH dehydrogenase subunit LQuickGO ontologyBLASTP
50288075029121315NADH dehydrogenase kappa subunitQuickGO ontologyBLASTP
50291145029638525NADH dehydrogenase subunit JQuickGO ontologyBLASTP
50296355030054420NADH dehydrogenase subunit IQuickGO ontologyBLASTP