Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4898841 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
489884149004751635macrolide efflux pump putativeQuickGO ontologyBLASTP
49006344900891258hypothetical proteinBLASTP
490095649026711716ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
490298349041851203hypothetical proteinBLASTP
490427749057131437carboxyl-terminal proteaseQuickGO ontologyBLASTP
49058324906725894cell division ABC transporter permease protein FtsXQuickGO ontologyBLASTP
49067154907401687cell division ABC transporter ATP-binding protein FtsEQuickGO ontologyBLASTP
49076884908011324cytochrome c-551QuickGO ontologyBLASTP
49082664908448183hypothetical proteinBLASTP
49084484909428981peptide chain release factor 2QuickGO ontologyBLASTP
490969149121982508translocaseQuickGO ontologyBLASTP
49124754913017543ribosomal subunit interface proteinQuickGO ontologyBLASTP
49133414913544204cold shock protein CspCQuickGO ontologyBLASTP
49136654914369705comF operon protein 3QuickGO ontologyBLASTP
491436949157241356comF operon protein 1QuickGO ontologyBLASTP
491584649171561311endopeptidase lytE putativeQuickGO ontologyBLASTP
49174084917731324hypothetical proteinBLASTP
49178964918738843degV family proteinQuickGO ontologyBLASTP
49189784919613636conserved hypothetical protein TIGR00257QuickGO ontologyBLASTP
491968849208151128transcription antiterminator LytR familyQuickGO ontologyBLASTP
492084949219641116UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
492203949234271389UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
492389949249721074glycosyl transferase group 4 family proteinQuickGO ontologyBLASTP
49251734925910738polysaccharide deacetylase putativeQuickGO ontologyBLASTP
492601549286902676transcription antiterminator BglG familyQuickGO ontologyBLASTP